Protein Details: P2X receptor A

Protein ID

ICDB_Pro_1201

Protein Name

P2X receptor A

Gene Name

p2xA; DDB_G0272004

Organism

Dictyostelium discoideum (Social amoeba)

Length

378 amino acids

AlphaFoldDB

AF-Q86JM7-F1-model_v4.pdb

Function

P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS; suramin and 2;3-O-(2;4;6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not essential for osmoregulation; however this information is in contradiction with another source which indicates that p2xA is required for osmoregulation. Found to be permeable to chloride ions. Inhibited by copper and sodium ions.

Sequence

MGFSFDWDDIFQYSTVKIVRIRDRRLGILHLSFLVGIVAYIVVYSAIIKKGYLFTEVPIGSVRTSLKGPNTFASNLTYCSNQQHNGSTYPFTPLECNYWDEQLALFPVGQDSTFTCTTRVRLSKQEANCNFTDPTCKFVDEPGSAKNIYIADIESFTILIDHTMYASSSGSQFNAVDLHGYILNQDGDEVQIDANGTSIGVSGKPDIMTIGQLLSFGGVSLDQASPVDSNVSIRYDGVVLFVFITYSNTYTYSTSDFKYVYSVQQIANTIYDVPETIILESIHSRLLYKRHGIRVIFIQTGTIGSFHFQTLLLTLVSGLGLLAVATTVVDQLAIRLLPQRKSYSSLKFQVTESMSNPMKKRITTDEGEDVLYTRIEGL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/nature05926; 10.1038/nature00847; 10.1038/nature03481; 10.1016/j.ceca.2008.04.001; 10.1074/jbc.m109.045674

RefSeq

XP_645378.1